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Scott Anderson's avatar

hmmm, and yet, elevated fasting insulin is a sure sign metabolic dysregulation. . .

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John Lawrence Aspden's avatar

Sounds about right, mild insulin resistance alone, but pancreas still working well, will cause the pancreas to make more insulin to force glucose out of the blood.

That glucose has got to go somewhere. It will turn into either fat or excessive energy or both I imagine. (Could also go to glycogen or get stuffed into the pentose phosphate pathway? I've no idea what that does.)

At that point nothing is obviously wrong, you're just hyperactive, or getting fat, with mysteriously high insulin levels. Maybe carrying lots of water-weight because of the extra glycogen.

If the pancreas itself gets knackered, then it won't make enough insulin, and then you get actual high blood glucose/diabetes.

But honestly I have no clue, I'm just hitting things with my new hammer to see what predictions it makes. I've no idea what's actually going on.

Since I'm not myself diabetic (yet?) I've not paid much attention to it.

I'm starting to think that depending what order things happen you might get *either* fat or diabetic at first, and then maybe eventually achieve both.

I wonder if you get either thin diabetics with loads of energy or tired, fat diabetics?

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Experimental Fat Loss's avatar

Have you tested your fasting blood glucose?

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John Lawrence Aspden's avatar

No but I recently had an HbA1c test and apparently blood glucose has been bang normal on average over the last three months or whatever it actually means.

And I don't think there were any keto bouts in that three months either, so that's my actual foreground metabolism somehow managing to control an entire thing.

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Experimental Fat Loss's avatar

What was your HbA1c number?

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John Lawrence Aspden's avatar

33mmol/mol. Apparently 48 is the level for diagnosing diabetes.

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Experimental Fat Loss's avatar

Hm, that seems to equal 5.2mmol/L, which I'd say is very good.

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John Lawrence Aspden's avatar

Yeah, I'm a counterexample to my own theory.... Booo....

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AliG-uk's avatar

Maybe look into the personal fat threshold theory. That could explain the thin type 2 diabetic. I partially believe that but I still think there's more to it because rapid weight loss in obese people leads to a reversal of IR / T2D within days/weeks in some cases even when they are still obese. Geogi Dinkov has some theories worth listening to also.

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John Lawrence Aspden's avatar

> rapid weight loss in obese people leads to a reversal of IR / T2D within days/weeks in some cases even when they are still obese

Really? That sounds interesting, can you cite/link? Does it all work in mice? Does it work in theory?

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AliG-uk's avatar

It happens in gastric band patients (they only eat about 600cal a day) and also in VLC diets such as the Newcastle Diet. Roy Taylor of Newcastle university has done research on how rapid weightloss has the same effect as GB surgery. If you Google his name you will find research papers and interviews.

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Experimental Fat Loss's avatar

I think PFT is bizarre and makes no sense. Glucose control typically improves long before serious fat loss.

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AliG-uk's avatar

I think that PFT is a thing but what I question is what causes it. I think it's only part of the equation. On one extreme you have people with lipodystrophy who are IR/diabetic when at a ridiculously low body fat but then you have people who can be 800lb and still not diabetic or have much visceral fat. So there's something going on with personal tolerance for making fat cell and how/why we make fat cells to store excess energy. Is that something to do with how each of us processes pufa? Do we have varying degrees of how pufa effects us? Is insulin sensitivity partly genetic in all of us (obs lipodystrophy is a genetic condition). Can we have an influence on those genes? Can we manipulate insulin sensitivity just through diet despite how much fat we are already carrying? (I think there's pretty good evidence this is possible). Maybe we need to improve insulin sensitivity before we attempt to lose fat rather than reducing stored fat to regain insulin sensitivity. Maybe some of both. There's a million questions.

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Experimental Fat Loss's avatar

Yea I think that's what I dislike about PFT, it's simply an accounting entity. Of course there is an amount at which a person will get fat if they get fat, and yes that amount is different in every person. That does not make PFT "real" or useful.

We don't talk about "Personal Money Threshold" even though some people get rich/poor much faster than others. Wow, crazy! This guy was a millionaire at 30 years old! His PMT must be really low!

Or maybe he was an investment banker, or went to law school, or inherited the money, or won the lottery... it just doesn't tell us anything useful.

It's literally a reformulation of "some people get fat and others get diabetes and some both and some neither" and then some pseudo-scientific lipstick on it.

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