PUFAs cause Insulin Resistance and Diabetes

Glycolysis is Blocked. Glycolysis is Blocked. Glycolysis is Blocked.

Insulin Resistance is the failure of cells to react properly to insulin.

In the presence of insulin, cells are supposed to absorb glucose and start burning it or turning it into glycogen.

If glycolysis is blocked then they can't burn it.

Diabetes is a dysregulation of glucose homeostasis.

How does that work?

The beta cells in the pancreas make insulin and burn glucose in order to do it.

In the presence of excessive glucose, they run hot. They have a lot of fuel coming in, so they make a lot of insulin.

The insulin that is released is supposed to cause the other cells of the body to absorb glucose and lower the level of glucose in the blood, a classic negative feedback loop.

If glycolysis is blocked, the beta cells will not make as much insulin, and blood glucose will rise. Dysregulation of homeostasis.

So, if "PUFAs block glycolysis" is true, then PUFAs will straightforwardly cause both insulin resistance and diabetes.

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Note that these two effects should combine!

Not enough insulin, and an inadequate response to the insulin. Blood sugar goes out of control.

I'm surprised and confused by this prediction.

I'm not diabetic, as far as I know.

That means that one of the things I think I know is false. Which one?