Another idea: the membrane might be made of LA, but in its natural state, it might not be heavily oxidized. The 2% or so of LA we'd be getting from a stone age diet was probably not heated to 450F for hours at a time during extraction and bleached with hexane. Or it might be something else in the mitochondria, surely that's not the only place where fatty acids are used structurally in there.
Yes, as I say, I'm not particularly sold on "seed oilz bad". It might be "fried seed oilz bad", something else entirely, or something that isn't even diet related. SMTM's lithium might be part of it, but I think it's unlikely to be the principal cause or even a main cause.
Chronic Fatigue Syndrome people will usually tell you that their condition started with a virus or even a vaccine, so I've got an 'immune system stuck on' theory as well. And a lot of them make spontaneous recoveries, which isn't really compatible with dietary poisons.
It's only the fact that I seem to be getting fixed by a weird diet that's giving me the idea that the two problems might be connected.
You might need mitochondrial damage *and* some sort of a semi-dormant viral infection together to cause the problem.
But the more complex the theory, the more I worry about *a priori* unlikeliness and over-fitting.
Just so; depends what your gasket is made out of. Every time I get ethanol on my rubber gloves they go sticky and fray.
Ethanol is a vile poison to most animals. As bad as methanol. We Europeans seem peculiarly well-adapted to detoxify it and use it as fuel. When you see a widespread adaptation, you know an awful lot of creatures died in the process of it becoming widespread.
Hi. So, I recently read that uncoupling protein results in proton leakage from the mitochondria, and also that calorie restriction leads to more efficient mitochondria with less leakage of protons. Which state is healthier? I currently plan to be "calorie restricted" for the rest of my life, so it's a WOE, not a temporary diet. I mean it's almost certain that humans evolved to handle, maybe even thrive? on restricted calories. I tend not to believe the modern models for BMR, or the focus on maximizing metabolic rate. I'm eating only 1lb of meat per day plus some kefir or sometimes coconut/cacao (6'3" 60yo male). Easy to maintain due to hunger reduction <-leptin sensitivity<- inflammation reduction. Feel great, sleep great, still have energy for exercise, etc. Is this WOE sustainable long term from a general health maintenance perspective?
I'm pretty sure that various ancestors back to the beginning of time survived without getting as many calories as they could use, so we must have ways of surviving that. I'd be suspicious of any claims that we would thrive in a Darwinian sense though, that extra energy should manage to find reproductive uses somehow.
But I'm not particularly surprised by claims that calorie restriction extends life. If you want your car to last, drive it slowly and not too often!
If your body is deliberately uncoupling and allowing proton leakage, so you're burning fuel but only turning into heat, then I'd guess it's trying to deliberately generate heat without making ATP for some reason, like running your engine out of gear just to keep the car warm.
High body temperature is good for its own sake. The colder you are, the more vulnerable to parasites of various kinds.
And your body was designed to run at around 37C. Much higher or lower than that the rates of various important reactions will change. Fatally, if you go too far.
Another idea: the membrane might be made of LA, but in its natural state, it might not be heavily oxidized. The 2% or so of LA we'd be getting from a stone age diet was probably not heated to 450F for hours at a time during extraction and bleached with hexane. Or it might be something else in the mitochondria, surely that's not the only place where fatty acids are used structurally in there.
Yes, as I say, I'm not particularly sold on "seed oilz bad". It might be "fried seed oilz bad", something else entirely, or something that isn't even diet related. SMTM's lithium might be part of it, but I think it's unlikely to be the principal cause or even a main cause.
Chronic Fatigue Syndrome people will usually tell you that their condition started with a virus or even a vaccine, so I've got an 'immune system stuck on' theory as well. And a lot of them make spontaneous recoveries, which isn't really compatible with dietary poisons.
It's only the fact that I seem to be getting fixed by a weird diet that's giving me the idea that the two problems might be connected.
You might need mitochondrial damage *and* some sort of a semi-dormant viral infection together to cause the problem.
But the more complex the theory, the more I worry about *a priori* unlikeliness and over-fitting.
> So what if using the wrong fuel somehow damaged the gasket?
You mean like ethanol fuel?
Just so; depends what your gasket is made out of. Every time I get ethanol on my rubber gloves they go sticky and fray.
Ethanol is a vile poison to most animals. As bad as methanol. We Europeans seem peculiarly well-adapted to detoxify it and use it as fuel. When you see a widespread adaptation, you know an awful lot of creatures died in the process of it becoming widespread.
Hi. So, I recently read that uncoupling protein results in proton leakage from the mitochondria, and also that calorie restriction leads to more efficient mitochondria with less leakage of protons. Which state is healthier? I currently plan to be "calorie restricted" for the rest of my life, so it's a WOE, not a temporary diet. I mean it's almost certain that humans evolved to handle, maybe even thrive? on restricted calories. I tend not to believe the modern models for BMR, or the focus on maximizing metabolic rate. I'm eating only 1lb of meat per day plus some kefir or sometimes coconut/cacao (6'3" 60yo male). Easy to maintain due to hunger reduction <-leptin sensitivity<- inflammation reduction. Feel great, sleep great, still have energy for exercise, etc. Is this WOE sustainable long term from a general health maintenance perspective?
I'm afraid I'm not even remotely equipped to offer advice about the long term sustainability of weird diets that I haven't even tried.
Except: Write down what you're doing, keep records, make graphs, publish them; make sure that you leave maps for future explorers.
And good luck!
I'm pretty sure that various ancestors back to the beginning of time survived without getting as many calories as they could use, so we must have ways of surviving that. I'd be suspicious of any claims that we would thrive in a Darwinian sense though, that extra energy should manage to find reproductive uses somehow.
But I'm not particularly surprised by claims that calorie restriction extends life. If you want your car to last, drive it slowly and not too often!
If your body is deliberately uncoupling and allowing proton leakage, so you're burning fuel but only turning into heat, then I'd guess it's trying to deliberately generate heat without making ATP for some reason, like running your engine out of gear just to keep the car warm.
High body temperature is good for its own sake. The colder you are, the more vulnerable to parasites of various kinds.
And your body was designed to run at around 37C. Much higher or lower than that the rates of various important reactions will change. Fatally, if you go too far.