17 Comments
User's avatar
Bob Beck's avatar

Do you have any thoughts about these GLP-1 drugs?

I have been making a lot of bone broth with added gelatin (chicken feet) and cooking long grain rice in it. It is my staple go to meal most days. Kind of a risotto like thing. I use a light Japanese fermented wheat sauce in moderation. Weight is down satiety is good, fewer arthritis flares.

Expand full comment
John Lawrence Aspden's avatar

My only thought about GLP-1 stuff is that we really have no idea how they work.

Personally I wouldn't touch them with someone else's bargepole, but then I'm only about 5kg over the point where I stop caring about my weight. If I was 200kg then I might well think that the benefits were worth the risk.

My main worries would be that (a) they're just a way of doing a starvation diet without using willpower, and starvation is not good for people, and (b) they may be working by interfering with the basic motivational architecture of your mind, which sounds like a cure worse than the disease.

They could be fine, but we don't know, and I don't trust medical trials to detect interesting side effects short of all cause mortality. I don't have any particular insight here.

> Weight is down satiety is good, fewer arthritis flares.

This all sounds unambiguously good! Congratulations.

Expand full comment
Experimental Fat Loss's avatar

How about you do a whole month of ex150 straight this time, heh.

Also, OmegaQuant Complete!

Expand full comment
John Lawrence Aspden's avatar

You have vast quantities of OmegaQuant samples now, you don't need one from me...

I can't see what I could possibly learn from one! I mean, I'm pretty sure I've got PUFAs in my fat, I'm pretty sure the amount will be declining, and I have no idea how the test numbers relate to the percentage PUFA in my fat cells, which is the thing I want to know.

Expand full comment
Experimental Fat Loss's avatar

It's not for me, it's for you! Don't you want to know how PUFA'd you are?

If you don't have a starting point, we don't know if it ever goes down.

Expand full comment
John Lawrence Aspden's avatar

I figure it's pretty much got to be going down because I'm no longer eating the things in any quantity, whereas I used to eat loads of commercially fried chips/steak fries which are basically potato soaked in burnt varnish.

If I thought the OmegaQuant test would tell me anything other than 'it's maybe going down' then I might bite, but it just looks like £200 and I have to stab myself a couple of times just to get two uninterpretable numbers, the second of which might be lower but that's not even guaranteed.

Expand full comment
Experimental Fat Loss's avatar

Yea but you figure and you don't know, do ya.

It's $100, not 200. You have to prick your finger tip once now and once in 5 years or whatever.

Expand full comment
John Lawrence Aspden's avatar

Yes but I won't know even if I do the test! Number go down, yay it's working. Number go up, number must be wrong.... It is at best slight evidence that the thing I already know must be happening is happening....

(I was counting £100 for the first stab and £100 for the second to see if it's any different.)

Expand full comment
John Lawrence Aspden's avatar

I'm normally desperate for something other than cream after a couple of weeks, even though I usually enjoy the mental and energy benefits of ketosis. I was thinking maybe ex150ish-fruit or ex150ish-sour-cream for a couple of weeks. I know it works in its raw form, but I haven't got your discipline; the trick would be to find something sustainable that also worked.

Expand full comment
Experimental Fat Loss's avatar

No discipline involved, I just like cream

Expand full comment
John Lawrence Aspden's avatar

Well me too actually, but after a couple of weeks of it I start to feel weirdly uncomfortable and start longing for carbs. I think I just don't feel quite right in ketosis, even though usually my mental state and tiredness issues improve quite a lot in keto. I'll probably just see how long I can do it for, but previous experience says that I want to stop after a couple of weeks.

At any rate, a couple of weeks followed by another couple of weeks seems to have roughly double the effect, so there's no harm in going in and out? And it's nice to see the water weight come back on so you can see the actual effect.

Like I say, actually pretty tempted by the +fruit version, so that might keep me out of ketosis, and whether that works as well as the full thing would be interesting, no?

Expand full comment
Experimental Fat Loss's avatar

I'd find it more interesting if you just did a whole month. Yes, adapting to ketosis takes some time, but once you make it through, it's great.

Expand full comment
John Lawrence Aspden's avatar

Off to the supermarket as we speak to buy butter and cream and 80/20 beef and no other things.... Sadly I have a brand new batch of organic apples and oranges which I am not going to leave to rot, so ex150ish+fruit it is.

I'll see how it goes. If it doesn't work I'll lay off the fruit and If I'm not desperate for variety in a couple of weeks I'll keep at it...

Ketosis is nice, I don't even get much in the way of keto flu if I take the electrolytes. It's more that after a couple of weeks I start thinking about carbs a lot, and I don't like ignoring those sorts of feelings. Your body tends to know what it needs.

Expand full comment
Experimental Fat Loss's avatar

> Your body tends to know what it needs.

False

> It's more that after a couple of weeks I start thinking about carbs a lot

Yup, indicating you're not fat adapted enough yet.

Expand full comment
Joe's avatar

That was a good point you made on yo-yo dieting. I think there are still other things at play with yo-yoing though.

Expand full comment