To understand how PUFAs affect metabolic actvity, it is helpful to become familiar with how arachidonic acid interacts with other unsaturated fatty acid molecules. I highly recommend this article by Norwegian animal science researchers. https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-9-37
For a deep dive into arachidonic acid, eicosanoid, and endocannabinoid system research, do some 'adipose tissue arachidonic acid' web searches in conjunction with any sort of pathological malady that comes to mind. A few examples:
Thank you. I love the way that they just casually assert pretty much the entire seed-oilz hypothesis in the abstract of their paper! Maybe we're winning hearts and minds...
Large amounts of polyunsaturated fats in modern food are responsible for most of the 'diseases of modernity'.
That, indeed, seems to be the case. However, we won't have proof until scientists deliberately experiment with reduced linoleic acid and arachidonic acid intake. The so-called Mediterranean diet inadvertently reduces linoleic acid and arachidonic acid intake but Steve Blechman is the only one I'm aware of to take notice. "The Mediterranean diet is low in arachidonic acid and rich in healthy fats such as monounsaturated fats found in extra-virgin olive oil (EVOO), nuts and omega-3 fatty acids from fish, which has been shown to lower the risk of inflammation, heart disease, cancer, diabetes and obesity, and other degenerative diseases." https://advancedmolecularlabs.com/blogs/news/new-red-meat-study-controversy
Thank you for sharing this very interesting study. I like how the researchers so confidently expressed some uncomfortable truths. Perhaps research in Norway is not captured by big Pharma like it is here in the US?
In my experience, animal science researchers seem to have a better grasp of omega-6 linoleic acid issues than obesity researchers. Here are two examples.
To understand how PUFAs affect metabolic actvity, it is helpful to become familiar with how arachidonic acid interacts with other unsaturated fatty acid molecules. I highly recommend this article by Norwegian animal science researchers. https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-9-37
For a deep dive into arachidonic acid, eicosanoid, and endocannabinoid system research, do some 'adipose tissue arachidonic acid' web searches in conjunction with any sort of pathological malady that comes to mind. A few examples:
adipose tissue arachidonic acid metabolic syndrome
adipose tissue arachidonic acid depression
adipose tissue arachidonic acid breast cancer
adipose tissue arachidonic acid prostate cancer
adipose tissue arachidonic acid heart disease
adipose tissue arachidonic acid Alzheimer's disease
Thank you. I love the way that they just casually assert pretty much the entire seed-oilz hypothesis in the abstract of their paper! Maybe we're winning hearts and minds...
What do you consider to be the seed oil hypothesis? It's pretty clear that excessive linoleic acid consumption does not directly cause inflammation or insulin resistance. https://lipidworld.biomedcentral.com/articles/10.1186/s12944-024-02246-2
People who respond to linoleic acid in that way are actually responding to the arachidonic acid that resulted from the elongation and desaturation of linoleic acid molecules. https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-023-01289-3
> What do you consider to be the seed oil hypothesis?
Large amounts of polyunsaturated fats in modern food are responsible for most of the 'diseases of modernity'.
Large amounts of polyunsaturated fats in modern food are responsible for most of the 'diseases of modernity'.
That, indeed, seems to be the case. However, we won't have proof until scientists deliberately experiment with reduced linoleic acid and arachidonic acid intake. The so-called Mediterranean diet inadvertently reduces linoleic acid and arachidonic acid intake but Steve Blechman is the only one I'm aware of to take notice. "The Mediterranean diet is low in arachidonic acid and rich in healthy fats such as monounsaturated fats found in extra-virgin olive oil (EVOO), nuts and omega-3 fatty acids from fish, which has been shown to lower the risk of inflammation, heart disease, cancer, diabetes and obesity, and other degenerative diseases." https://advancedmolecularlabs.com/blogs/news/new-red-meat-study-controversy
Thank you for sharing this very interesting study. I like how the researchers so confidently expressed some uncomfortable truths. Perhaps research in Norway is not captured by big Pharma like it is here in the US?
In my experience, animal science researchers seem to have a better grasp of omega-6 linoleic acid issues than obesity researchers. Here are two examples.
https://www.intechopen.com/chapters/41405
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167608
Very interesting studies, thank you for providing the links.
I don’t know anything about sulphites, but that sounds a lot like the bucket model for histamine or salicylates.
https://histaminebalance.com/the-histamine-bucket/