In phosphatidylcholine and phosphatidylethanolamine, which are present in the mitochondrial membrane in greater proportions than cardiolipin, the portion of saturated fatty acids is greater.
According to Wikipedia, cardiolipin is only about 20% of the mitochondria inner membrane. As it is so conserved, there are clearly mechanisms that concentrate LA there. What about the other 80% of the lipids in the membrane? Your original thesis is quite sound. Mitochondria leak horribly and lead to many diseases. I think the focus upon reducing LA in our diet is still a sound strategy.
In phosphatidylcholine and phosphatidylethanolamine, which are present in the mitochondrial membrane in greater proportions than cardiolipin, the portion of saturated fatty acids is greater.
https://www.lipidmaps.org/resources/lipidweb/lipidweb_html/lipids/complex/pc/index.htm
https://lipidmaps.org/resources/lipidweb/lipidweb_html/lipids/complex/pe/index.htm
Good stuff.
"Broda Barnes, Gordon Skinner, and John Lowe all claimed to be able to fix these things using thyroid drugs."
Where might I find the best layman's explanation of this?
Broda Barnes book 'Hypothyroidism: The Undetected Illness' is very layman.
Skinner published a nice readable book, 'Diagnosis and Management of Hypothyroidism', aimed at fellow doctors.
Lowe published "The metabolic treatment of hypothyroidism", huge and technical.
I put lots of links to papers and other stuff on: r/thethyroidmadness/
But I think you need to use old reddit to see them. Try: https://old.reddit.com/r/thethyroidmadness/
According to Wikipedia, cardiolipin is only about 20% of the mitochondria inner membrane. As it is so conserved, there are clearly mechanisms that concentrate LA there. What about the other 80% of the lipids in the membrane? Your original thesis is quite sound. Mitochondria leak horribly and lead to many diseases. I think the focus upon reducing LA in our diet is still a sound strategy.
Quite so.
> I think the focus upon reducing LA in our diet is still a sound strategy.
Me too!