Perhaps of interest, although the researchers don't discuss why PUFAs are found in the ciliated cell membranes:
"The researchers found that pollutants cause the polyunsaturated fatty acids (PUFAs) found in ciliated cell membranes to undergo oxidation, resulting in the formation of reactive molecules called lipid peroxide-derived aldehydes in the airways. Their reactivity allows them to modify the cells, leading to dysfunction and damage that can extend to the cilia."
Nice find! There are a lot of papers out there which notice PUFAs getting oxidised and causing havoc. I find I don't even really doubt the idea that PUFAs are implicated in sunburn, cancer and heart disease any more. It just seems obvious and I wonder why medical types don't see it.
I think there's an awful lot of nutrition research that says that saturated fat is bad and PUFA is good, and I reckon the 'paradox' is caused by the fat that animal fat has been high in PUFA since the turn of the last century. All the research is confounded by this fact.
I actually wonder if the benefits of a plant-based diet are to do with the fact that plants don't contain much vegetable oil. Oh the irony.
I've always hated the pretend sciences for using the methods of sociology while claiming the authority of physics. These days I *really* hate them.
Still, biochemistry has been doing fine work. Once you know the mechanisms you can work out what your statistics were trying to tell you.
A good call! I think I strongly predict that a population that smokes heavily but doesn't consume PUFAs won't suffer from heart disease much, although they will have lots of harmless atherosclerotic plaques in their arteries.
I don't know if such a population exists, I wonder if there was one in Victorian times?
Or maybe some Amish-like people who don't eat PUFA-filled foods but do smoke for some reason?
Also totally clearing PUFAs from your system *might* allow the damage to heal, as unstable plaques oxidise and are repaired with more stable fats. So maybe ten years after forswearing all polyunsaturated evil your blood pressure might start to come back down or at least stop rising?
Yeah, those seem like good low hanging fruit to investigate. I'm still a little skeptical about the smoking being a part of the problem, mostly because of all the people I know who don't smoke but are still metabolically lost.
"Moreover, lipids from human atherosclerotic plaques have been found to contain oxidised cholesteryl linoleate (cholesterol esters containing linoleic acid).21–24 Moreover, the severity of atherosclerosis is noted to increase with increasing oxidised cholesteryl linoleate.21 25 In other words, cholesterol was protected from oxidation if bound to saturated fat but susceptible to oxidation when bound to linoleic acid. Again, this suggests is that eating more linoleic acid increases the oxidation of cholesterol within LDL particles further increasing atherosclerosis formation and the risk of coronary heart disease"
They found mummies with tobacco leaves, and cocaine. There was contact with the old world, Atlantis was the stop between.
Did they really? I will consult my local Atlantis expert. Links appreciated.
Excellent! Looking forward to reading that book!
Perhaps of interest, although the researchers don't discuss why PUFAs are found in the ciliated cell membranes:
"The researchers found that pollutants cause the polyunsaturated fatty acids (PUFAs) found in ciliated cell membranes to undergo oxidation, resulting in the formation of reactive molecules called lipid peroxide-derived aldehydes in the airways. Their reactivity allows them to modify the cells, leading to dysfunction and damage that can extend to the cilia."
https://newatlas.com/health-wellbeing/pm2-5-air-pollution-lungs-mucociliary-clearance/
Nice find! There are a lot of papers out there which notice PUFAs getting oxidised and causing havoc. I find I don't even really doubt the idea that PUFAs are implicated in sunburn, cancer and heart disease any more. It just seems obvious and I wonder why medical types don't see it.
I think there's an awful lot of nutrition research that says that saturated fat is bad and PUFA is good, and I reckon the 'paradox' is caused by the fat that animal fat has been high in PUFA since the turn of the last century. All the research is confounded by this fact.
I actually wonder if the benefits of a plant-based diet are to do with the fact that plants don't contain much vegetable oil. Oh the irony.
I've always hated the pretend sciences for using the methods of sociology while claiming the authority of physics. These days I *really* hate them.
Still, biochemistry has been doing fine work. Once you know the mechanisms you can work out what your statistics were trying to tell you.
Be a good rationalist, and make testable predictions for your proposed mechanism. How would you test the Atherosclerosis filled with PUFAs hypothesis?
A good call! I think I strongly predict that a population that smokes heavily but doesn't consume PUFAs won't suffer from heart disease much, although they will have lots of harmless atherosclerotic plaques in their arteries.
I don't know if such a population exists, I wonder if there was one in Victorian times?
Or maybe some Amish-like people who don't eat PUFA-filled foods but do smoke for some reason?
Also totally clearing PUFAs from your system *might* allow the damage to heal, as unstable plaques oxidise and are repaired with more stable fats. So maybe ten years after forswearing all polyunsaturated evil your blood pressure might start to come back down or at least stop rising?
Can you think of anything else obvious?
Yeah, those seem like good low hanging fruit to investigate. I'm still a little skeptical about the smoking being a part of the problem, mostly because of all the people I know who don't smoke but are still metabolically lost.
From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196963/
"Moreover, lipids from human atherosclerotic plaques have been found to contain oxidised cholesteryl linoleate (cholesterol esters containing linoleic acid).21–24 Moreover, the severity of atherosclerosis is noted to increase with increasing oxidised cholesteryl linoleate.21 25 In other words, cholesterol was protected from oxidation if bound to saturated fat but susceptible to oxidation when bound to linoleic acid. Again, this suggests is that eating more linoleic acid increases the oxidation of cholesterol within LDL particles further increasing atherosclerosis formation and the risk of coronary heart disease"
Oh nice find! Thank you.