A good call! I think I strongly predict that a population that smokes heavily but doesn't consume PUFAs won't suffer from heart disease much, although they will have lots of harmless atherosclerotic plaques in their arteries.
I don't know if such a population exists, I wonder if there was one in Victorian times?
Or maybe some Amish-like people who don't eat PUFA-filled foods but do smoke for some reason?
Also totally clearing PUFAs from your system *might* allow the damage to heal, as unstable plaques oxidise and are repaired with more stable fats. So maybe ten years after forswearing all polyunsaturated evil your blood pressure might start to come back down or at least stop rising?
Yeah, those seem like good low hanging fruit to investigate. I'm still a little skeptical about the smoking being a part of the problem, mostly because of all the people I know who don't smoke but are still metabolically lost.
"Moreover, lipids from human atherosclerotic plaques have been found to contain oxidised cholesteryl linoleate (cholesterol esters containing linoleic acid).21–24 Moreover, the severity of atherosclerosis is noted to increase with increasing oxidised cholesteryl linoleate.21 25 In other words, cholesterol was protected from oxidation if bound to saturated fat but susceptible to oxidation when bound to linoleic acid. Again, this suggests is that eating more linoleic acid increases the oxidation of cholesterol within LDL particles further increasing atherosclerosis formation and the risk of coronary heart disease"
They found mummies with tobacco leaves, and cocaine. There was contact with the old world, Atlantis was the stop between.
Did they really? I will consult my local Atlantis expert. Links appreciated.
Excellent! Looking forward to reading that book!
Be a good rationalist, and make testable predictions for your proposed mechanism. How would you test the Atherosclerosis filled with PUFAs hypothesis?
A good call! I think I strongly predict that a population that smokes heavily but doesn't consume PUFAs won't suffer from heart disease much, although they will have lots of harmless atherosclerotic plaques in their arteries.
I don't know if such a population exists, I wonder if there was one in Victorian times?
Or maybe some Amish-like people who don't eat PUFA-filled foods but do smoke for some reason?
Also totally clearing PUFAs from your system *might* allow the damage to heal, as unstable plaques oxidise and are repaired with more stable fats. So maybe ten years after forswearing all polyunsaturated evil your blood pressure might start to come back down or at least stop rising?
Can you think of anything else obvious?
Yeah, those seem like good low hanging fruit to investigate. I'm still a little skeptical about the smoking being a part of the problem, mostly because of all the people I know who don't smoke but are still metabolically lost.
From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196963/
"Moreover, lipids from human atherosclerotic plaques have been found to contain oxidised cholesteryl linoleate (cholesterol esters containing linoleic acid).21–24 Moreover, the severity of atherosclerosis is noted to increase with increasing oxidised cholesteryl linoleate.21 25 In other words, cholesterol was protected from oxidation if bound to saturated fat but susceptible to oxidation when bound to linoleic acid. Again, this suggests is that eating more linoleic acid increases the oxidation of cholesterol within LDL particles further increasing atherosclerosis formation and the risk of coronary heart disease"
Oh nice find! Thank you.