Stumbled across this while researching Keto as I try to manage my diabetes and it's pertinent to your theories about glucose and mental health. It sounds like there's a lot of people who experience marked improvement in anxiety, depression, and a host of other mental problems when they get into keto -- to the point where it pops up spontaneously in Reddit threads.
Thanks! I'll try sticking that post about ketosis fixing mental issues there and see if I get any good comments. I wish I was more confident about pufas blocking glycolysis outside the liver, all this would be a slam dunk if it was true.
> No wonder DHA is an anti-inflammatory. It's literally turning off your immune system by stopping cells replicating. And doubtless causing all sort of other chaos.
I doubt a bit of fish is going to do you much harm, we need some DHA and other polyunsaturates (LA for the inner mitochondrial membrane, and DHA and EPA I think get used for signalling molecules, my ignorance is vast), and I'm pretty sure that there are plenty of healthy populations eating fish.
But we're not a littoral species, and fish doesn't travel well, so we can't be dependent on it.
And there's a difference between eating fish (as I remember from my fish-gutting days you eat the nice white muscle flesh and throw the insides away because they're disgusting) and swilling concentrated fish liver oil. In the same way that there's a difference between eating plants and eating the concentrated oil from their seeds.
What's puzzling me is why essential molecules like DHA and LA are setting off these cancer defences. I mean maybe it's just an accident, the interaction was always there but it was never significant because there was never much around, but it still seems like a bug.
Or maybe there's something about cancer that causes there to be a lot of this stuff around? Cancers love anaerobic glycolysis (Warburg effect), and they're using that to build new cancer cells I imagine. Are they also splurging out loads of weird fats for some reason?
> Relatedly, experimental subject #001 reports that ex150ish appears to have fixed his severe life-wrecking treatment resistant bipolar disorder that he has been suffering from for decades, and that he’s been feeling fine for nearly four weeks now
This makes me happy :)
All the doctors in the world and then you do some batshit diet from some asshole on the internet and your "idiopathic" and "it's complicated" thing just goes away. Pretty much just like my Non-24. Makes you wonder what else they're wrong about.
Well, a lot, half of all published papers are wrong and all that. And it's really hard to get research funding for anything that isn't going to make a drug company money.
But in their defence, they're also right about an awful lot of things. They've unambiguously saved my life on one occasion, and probably on several more that I just don't know about because they prevented or stopped some trivial infection from killing me.
Essentially I trust them where there's obvious mechanism, and I don't trust them where they're relying on 'studies'. Especially if the studies need meta-analyses.
But if someone has something seriously wrong with them, the absolute first thing they should do is go and see a doctor. It's when the doctor's advice doesn't obviously straightforwardly work that you need to start thinking.
I trust them when the shit they're saying is obviously working for most people (antibiotics, aspirin) and not when it's obviously not (anything related to nutrition/sleep).
If you need to show me a study then I don't trust that it works, I merely treat it as hypothesis generation.
Calen Horton writes (personal e-mail) :
Stumbled across this while researching Keto as I try to manage my diabetes and it's pertinent to your theories about glucose and mental health. It sounds like there's a lot of people who experience marked improvement in anxiety, depression, and a host of other mental problems when they get into keto -- to the point where it pops up spontaneously in Reddit threads.
https://www.reddit.com/r/keto/comments/1de520p/mental_health_massively_improved_on_keto_does/
Thanks! I'll try sticking that post about ketosis fixing mental issues there and see if I get any good comments. I wish I was more confident about pufas blocking glycolysis outside the liver, all this would be a slam dunk if it was true.
> No wonder DHA is an anti-inflammatory. It's literally turning off your immune system by stopping cells replicating. And doubtless causing all sort of other chaos.
Huh, wow! Makes me even more skeptical of fish!
I doubt a bit of fish is going to do you much harm, we need some DHA and other polyunsaturates (LA for the inner mitochondrial membrane, and DHA and EPA I think get used for signalling molecules, my ignorance is vast), and I'm pretty sure that there are plenty of healthy populations eating fish.
But we're not a littoral species, and fish doesn't travel well, so we can't be dependent on it.
And there's a difference between eating fish (as I remember from my fish-gutting days you eat the nice white muscle flesh and throw the insides away because they're disgusting) and swilling concentrated fish liver oil. In the same way that there's a difference between eating plants and eating the concentrated oil from their seeds.
What's puzzling me is why essential molecules like DHA and LA are setting off these cancer defences. I mean maybe it's just an accident, the interaction was always there but it was never significant because there was never much around, but it still seems like a bug.
Or maybe there's something about cancer that causes there to be a lot of this stuff around? Cancers love anaerobic glycolysis (Warburg effect), and they're using that to build new cancer cells I imagine. Are they also splurging out loads of weird fats for some reason?
> Relatedly, experimental subject #001 reports that ex150ish appears to have fixed his severe life-wrecking treatment resistant bipolar disorder that he has been suffering from for decades, and that he’s been feeling fine for nearly four weeks now
This makes me happy :)
All the doctors in the world and then you do some batshit diet from some asshole on the internet and your "idiopathic" and "it's complicated" thing just goes away. Pretty much just like my Non-24. Makes you wonder what else they're wrong about.
> Makes you wonder what else they're wrong about.
Well, a lot, half of all published papers are wrong and all that. And it's really hard to get research funding for anything that isn't going to make a drug company money.
But in their defence, they're also right about an awful lot of things. They've unambiguously saved my life on one occasion, and probably on several more that I just don't know about because they prevented or stopped some trivial infection from killing me.
Essentially I trust them where there's obvious mechanism, and I don't trust them where they're relying on 'studies'. Especially if the studies need meta-analyses.
But if someone has something seriously wrong with them, the absolute first thing they should do is go and see a doctor. It's when the doctor's advice doesn't obviously straightforwardly work that you need to start thinking.
I trust them when the shit they're saying is obviously working for most people (antibiotics, aspirin) and not when it's obviously not (anything related to nutrition/sleep).
If you need to show me a study then I don't trust that it works, I merely treat it as hypothesis generation.
Yes I think we're saying roughly the same thing!